Mamofen-20

INDICATIONS :
1) Indicated for the treatment of breast carcinoma, particularly in oestrogen receptor positive
patients.
2) For the treatment of anovulatory infertility.
aminoglutethimide. Induction of CYP3A4-mediated metabolism is considered to be the mechanism
by which these reductions occur; other CYP3A4 inducing agents have not been studied to confirm
this effect. One patient receiving tamoxifen with concomitant phenobarbital exhibited a steady state
serum level of tamoxifen lower than that observed for other patients (ie, 26 ng/mL vs. mean value of
122 ng/mL). However, the clinical significance of this finding is not known. Rifampin induced the
metabolism of tamoxifen and significantly reduced the plasma concentrations of tamoxifen in 10
patients. Aminoglutethimide reduces tamoxifen and N-desmethyl tamoxifen plasma concentrations.
Medroxyprogesterone reduces plasma concentrations of N-desmethyl, but not tamoxifen.
Concomitant bromocriptine therapy has been shown to elevate serum tamoxifen and N-desmethyl
tamoxifen.

Packaging: Box of 100’s
Shelf Life: 48 mos
Origin: India
Regional MOQ: 15,625